Advancement of opioid analgesia
with controlled-release oxycodone

by
Levy MH.
Department of Medical Oncology,
Fox Chase Cancer Center,
Philadelphia, PA, USA.
mh_levy@fccc.edu
Eur J Pain 2001;5 Suppl A:113-6


ABSTRACT

Optimal pharmacologic management of pain requires selection of the appropriate analgesic drug, prescription of the appropriate dose, administration of the analgesic by the appropriate route, scheduling of the appropriate dosing interval, prevention of persistent pain and relief of breakthrough pain, aggressive titration of the dose of the analgesic, prevention, anticipation, and management of analgesic side-effects, use of appropriate co-analgesic drugs, and consideration of sequential trials of opioid analgesics. Controlled-release oxycodone (CRO) has the characteristics of an 'ideal' opioid analgesic drug: short half-life, long duration of action, predictable pharmacokinetics, absence of clinically active metabolites, rapid onset of action, easy titration, no ceiling dose, minimal adverse effects, and minimal associated stigma. CRO has been shown to be effective in the control of pain caused by cancer, osteoarthritis, post-herpetic neuralgia, major surgery, and degenerative spine disease.
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Morphine
Oxycodone
Oxycontin use
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The OxyCon Game
The Oxycontin Doctor
Oxycodone: structure
Oxycodone: metabolism
Tramadol versus oxycodone
Oxycodone versus morphine
Oxycodone: pharmacokinetics
Oxycodone controlled-release
Oxycontin: politics and science
OxyContin: prescribing indications