Behavioral effects of delta-opioid receptor
agonists: potential antidepressants?
Broom DC, Jutkiewicz EM, Rice KC, Traynor JR, Woods JH.
Department of Pharmacology,
University of Michigan Medical School,
Ann Arbor 48109-0632, USA.
Jpn J Pharmacol 2002 Sep;90(1):1-6
ABSTRACTThe development of selective delta-opioid receptor agonists has revealed some very intriguing behavioral properties. delta-Opioid agonists have antinociceptive, seizuregenic and convulsive properties. A number of studies have identified a novel behavioral effect of delta-opioid-receptor agonists, implicating a role for the delta-opioid receptor in depression. Early clinical experiments demonstrated that exogenously administered opioid peptides had antidepressant activity in human patients. Also, enkephalinase inhibitors, which prevent the degradation of endogenous enkephalins, produced antidepressant-like effects mediated through the delta-opioid receptor in animal models of depression. More recently, the selective non-peptidic delta-opioid agonists SNC80 and (+)BW373U86 demonstrated antidepressant-like activity in the forced swim assay in rats. These studies propose that the delta-opioid receptor may provide a new therapeutic target for treating human depression.Mu
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Peptidic delta opioid receptor agonists as antidepressants
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