The separation of codeine from nonprescription
combination analgesic
products
by
Fleming GF, McElnay JC, Hughes CM.
School
of Pharmacy,
The Queen's University of Belfast,
Belfast, Northern Ireland.
Subst Use Misuse. 2003 Jul;38(9):1217-26
ABSTRACT
In the United Kingdom number of products containing codeine in combination
with nonopioid analgesics are available from pharmacies for purchase without a
prescription. These products may be abused and it has been reported that in order
to avoid nonopioid toxicity, some users may attempt to separate the components
of combination analgesics, by mixing the dosage form in water and passing it through
a coffee filtration apparatus (coffee filters). The present research sought to
test the ease of separation of products available in the United Kingdom. The results
obtained indicated that separation was possible; however, the extent of separation
was influenced by the volume of water used and the product chosen. Healthcare
professionals must be aware that separation may be attempted by those wishing
to abuse codeine; however, significant nonopioid toxicity could still arise in
the abuser.
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